Healing of Apical Periodontitis after Nonsurgical Root Canal Treatment: The Role of Statin Intake

Journal of Endodontics 


  • In this longitudinal clinical study, healing of preoperative apical periodontitis was evaluated in patients on statins and control patients.
  • The study controlled for the following confounding variables: age, sex, length of time to evaluation, statin agent, diabetes, and cardiovascular disease.
  • A multivariate analysis showed a significant association between healing and the intake of statins (P < .05).



Numerous previously undocumented factors may influence the healing of apical periodontitis (AP). The aim of this cohort study was to analyze the association between statin medication intake during the follow-up period and healing of AP.


Patients who self-reported being on statins during nonsurgical root canal treatment or retreatment and patients who reported never taking statins were included. All patients who received treatment on a tooth with periapical radiolucency in the postgraduate endodontics clinic at the University of Maryland School of Dentistry (2011–2014) were invited for follow-up 2 to 5 years after treatment. Healing was determined using the periapical index (PAI). Two calibrated endodontists assessed outcomes blinded to the statin intake. The association of statin intake and healing of endodontic treatment (ie, healed [PAI 1–2]/not healed [PAI 3–5]) was analyzed using the Fisher exact test. Logistic regression analysis was used to explore the association between statin intake and treatment outcome, controlling for the following confounding variables: diabetes mellitus, cardiovascular disease, and smoking, with confidence intervals set at 95%.


A total of 60 cases were involved in the final analysis, including 30 patients taking statins and 30 patients not taking statins as the control. The Fisher exact test showed significantly higher healing at the 2-year or greater follow-up in patients taking statins compared with controls (93.0% vs 70%; Fisher exact test, P = .02).


The results of this study show a significant association between long-term statin intake and healing of AP after nonsurgical root canal treatment.
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Ozone application as adjunctive therapy in chronic periodontitis: Clinical, microbiological and biochemical aspects

Journal of Dental Sciences



The application of ozone as an adjunctive treatment represents a new approach in the management of chronic periodontitis. The purpose of this study was to evaluate the clinical, biochemical and microbiological efficacy of ozone treatment as an adjunct to scaling and root planing (SRP) in generalized chronic periodontitis (GCP) patients.

Materials and methods

Eighteen patients (9 males and 9 females; aged from 28 to 47 years, mean age of 40 ± 6.51 years) with GCP were recruited in the study. In a split mouth design, two quadrants in each patient were randomly allocated to SRP-alone or SRP-ozone therapy (SRP + OT) groups by coin toss method. Subgingival plaque and gingival crevicular fluid (GCF) samples were collected at baseline, following 1st and 3rd months. The clinical parameters were monitored at baseline and after 3 months. Microbiological parameters were analyzed by quantitative-PCR and GCF biomarkers were determined by ELISA. Results were analyzed statistically.


Statistically significant improvements in all clinical parameters were accompanied by a reduction in microbiological and biochemical parameters in both treatment groups. SRP treatment resulted in a significant reduction of Porphyromonas gingivalis (Pg) at 1st month and Tannerella forsythia (Tf) and Prevotella intermedia (Pi) at 3 months. Following SRP treatment the interleukin (IL)-8 levels were significantly reduced at month 1. There were no significant differences between two treatments for any of the parameters.


Within the limitations of this study, adjunctive ozone therapy did not provide additional benefits to clinical, microbiological and biochemical parameters over SRP in chronic periodontitis patients.
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Dentsply Sirona announces expansion of its technology sales team

Technology sales force to more than double, as Dentsply Sirona pledges to continue to offer the best customer service, support and education while improving customer and dealer experience 

CHARLOTTE, N.C. (July 31, 2018) – Dentsply Sirona, the Dental Solutions Company, announced today its plan to grow its technology sales team in key U.S. markets to better serve customers and dealer partners nationwide. Clients and dealers can expect to see more than twice the number of representatives in each of the technologies divisions when the staff expansion is complete. This increase will create a better bridge between those divisions.
An emphasis will be put on building better relationships to improve the company’s already top-tier customer support and buying process.
“Our larger technology sales team shows Dentsply Sirona’s commitment to providing our customers with the best-in-class service, support and education on our market-leading technologies,” said CAD/CAM and Imaging Sales Vice President Linda Gehringer.
Customers will also see more in-field support personnel, allowing a renewed focus be put on sales-related matters with dealer representatives. Dentsply Sirona sees the growing demand for dental implants and single-visit dentistry and is working to provide better CAD/CAM coverage to address this growth.
The larger technology sales team will also continue to support customer education by offering assistance to best understand all Dentsply Sirona equipment and technology.
These changes are expected to be fully up and running later this summer, but dealers and customers should notice an impact on or before Labor Day.

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Unprecented Dentsply Sirona World 2018 special registration offer now extended through August

Save thousands by registering for Dentsply Sirona World 2018 with this special bundle offer for one doctor and two staff members 

CHARLOTTE, N.C. (August 1, 2018) – Who said second chances at the perfect deal don’t exist? Dentsply Sirona, the Dental Solutions CompanyTM, is extending its unbelievable Dentsply Sirona World 2018 registration deal through August 31 that allows one doctor and two staff members to attend the industry’s largest educational festival for only $2,995.
Your chance to save more than $1,000 ends soon, so make sure to register yourself and your team as soon as possible.
Registering at this low price offers access to:

  • General and Breakout sessions within 12 unique educational tracks
  • Expansive trade show floor, featuring the latest and most advanced products in the dental industry
  • Private performances by Pop Superstar Katy Perry and ultra- funny Comedian Jim Gaffigan
  • Dentsply Sirona World closing Oktoberfest-themed party
  • Wellness activities including a medieval-themed fun run and
    yoga session with Orlando’s top yoga instructors
  • Meet and mingle with some of the industry’s best and
    brightest KOLs
    For an additional $500 per person attendees can get VIP status, which includes faster registration and badge pick-up, reserved seats for ALL General sessions, and more.
    Hosted at the Rosen Shingle Creek in Orlando from September 13- 15, Dentsply Sirona World truly offers an experience like no other in the dental field. Register now at www.dentsplysironaworld.com or contact the Dentsply Sirona World hotline at 1-844-462-7476 or email events@dentsplysironaworld.com.
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Research and Education Diagnostic accuracy of 4 intraoral radiographic techniques for misfit detection at the implant abutment joint

The Journal of Prosthetic Dentistry


Statement of problem

A misfit or gap at the implant–abutment joint (IAJ) requires detection as it may compromise the health of the peri-implant tissue. However, which radiographic technique provides the most orthogonal relationship between the central beam and the implant/image receptor is unclear.


The purpose of this in vitro study was to evaluate the diagnostic accuracy of 4 intraoral radiographic techniques on misfit detection at the IAJ.

Material and methods

Twenty implants were placed in polyamide jaws, and customized dental implant abutments with a metal collar were installed. Different gaps were simulated by placing one or three 50-μm-thick polyester strips at the IAJ; the absence of the strip represented the control group (no gap). The 4 radiographic techniques were evaluated by using different film holders: a periapical with bisecting angle (PBA), a bitewing interproximal (BI), a periapical with standard paralleling (PSP), and a periapical with modified paralleling (PMP) holder (with a custom-made paralleling index). A total of 240 digital radiographs were evaluated by 4 clinicians experienced with dental implants. Differences were evaluated by using receiver operating characteristic (ROC) curves (Az) and Fisher tests (α=.05). Diagnostic values (sensitivity, specificity, accuracy, and positive and negative predictive values) were also obtained. The Kappa test was used to assess intra- and interevaluator reproducibility, which ranged from moderate to almost perfect.


All diagnostic values, except specificity, were lower for the PBA technique for both the 50- and 150-μm gaps. Az values for the PBA technique were significantly lower than those obtained for the other 3 techniques (P<.05), which did not differ from each other. The 150-μm gaps were more easily detected than the 50-μm gaps only for PBA (P<.05).


The BI, PSP, and PMP techniques detected misfits at the IAJ most accurately. The PBA technique is not recommended for this purpose.
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