Therapeutic effect of Aloe vera and silver nanoparticles on acid-induced oral ulcer in gamma-irradiated mice

Braz. oral res. vol.32  São Paulo  2018  Epub Feb 05, 2018 

Radiation combined injury, a life-threatening condition, has higher mortality than simple radiation injury. The aim of the present study was to analyze the efficiency of Aloe vera and silver nanoparticles in improving the healing of ulcerated oral mucosa after irradiation. Thirty male Albino mice were divided into five groups: control, radiation, Aloe vera (AV), silver nanoparticles (NS), and AV+NS. The mice were exposed to whole body 6Gy gamma-radiation. After one hour, 20% acetic acid was injected into the submucosal layer of the lower lip for ulcer induction. The animals received topical treatment with the assigned substances for 5 days. Lip specimens were subjected to hematoxylin and eosin and anti alpha-smooth muscle actin immunohistochemical staining. Results demonstrated occurance of ulcer three days post irradiation in all groups except in the AV+NS group where only epithelial detachment was developed. After seven days, data revealed persistent ulcer in radiation group, and almost normal epithelium in the AV+NS group. A significant reduction of epithelial thickness was detected in all groups at the third day as compared to control. At the seventh day, only the AV+NS group restored the epithelial thickness. Area percent of alpha-smooth muscle actin expression was significantly decreased in radiation group at the third day followed by significant increase at the seventh day. However, all treatment groups showed significant increase in alpha-smooth muscle actin at the third day, which decreased to normal level at the seventh day. Our study demonstrated the efficiency of Aloe vera and silver nanoparticles in enhancing ulcer healing after irradiation.

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Kulzer launches Ivory® ReLeafTM, dentistry’s best hands-free suction solution

South Bend, IN/2.9.2018. Kulzer announced today that it has launched its time-saving, patient-friendly, high volume Ivory ReLeaf hands-free HVE suction device.
Ivory ReLeaf assists with evacuation, retraction and maintaining a dry field during a wide array of dental and hygiene procedures. Unlike saliva ejectors, Ivory ReLeaf is not only a hands-free suction device, but a high volume suction device. It works in all four quadrants with ergonomic comfort and full view of oral cavity without the need to be moved around. This can save up to 15 minutes of time per patient, which can translate into hundreds of dollars in increased production throughout the day.
“The ingenious aspect of Ivory ReLeaf’s design is that its disposable leaves use the cheek and vestibule area for support, rather than relying on the shape of the arch or the orientation of the teeth,” said Lesley Melvin, Kulzer’s Director, Marketing & Product Management. “This provides 280 degrees of suction around the leaf to make time-saving uninterrupted suction throughout the oral cavity possible.” Ivory ReLeaf further contributes to practice efficiency by conveniently connecting to existing dental vacuum systems in less than 60 seconds.
Ivory ReLeaf is exceptionally patient-friendly. Patients are less likely to feel claustrophobic since the device does not obstruct the airway, and because Ivory ReLeaf does not reach the soft pallet, gag reflexes are rarely an issue. In addition, its universal mouthpiece, or “leaf,” is made of a custom blend of latex and BPA-free polymer that is both soft and comfortable. And because Ivory ReLeaf allows patients to move their heads left and right and up and down, they can communicate on a two-way basis with the clinician during the treatment.
According to Ms. Melvin, Ivory ReLeaf also provides peace of mind to patients and clinicians alike. According to the Center for Disease Control, when patients close their lips around low- volume saliva ejectors, backflow can occur when the pressure in the patient’s mouth is less than
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that in the evacuator. “This backflow, which can include previous patients’ waste material, colonized biofilm from the tubing, and chemicals from flushing the line, is simply not possible with Ivory ReLeaf,” said Ms. Melvin.
Dental practices may order a free sample of Ivory ReLeaf at Learn more about Ivory ReLeaf and other Kulzer products at
Kulzer, LLC
As one of the world’s leading dental companies, Kulzer has been a reliable partner for all dental professionals for more than 80 years. Whether aesthetic or digital dentistry, tooth preservation, prosthetics or periodontology – Kulzer stands for trusted and innovative dental products. With optimal solutions and services, Kulzer aims to support its customers in restoring their patients’ oral health in a safe, simple and efficient way. For this purpose, 1500 employees work in 26 locations in the field of research, manufacture and marketing.
Kulzer is part of the Mitsui Chemicals Group. The Japanese Mitsui Chemicals Inc. (MCI) based in Tokyo owns 131 affiliates with more than 13,400 employees in 27 countries. Its innovative and functional chemical products are as much in demand in the automotive, electronics and packaging industries as in environmental protection and healthcare.
Up to July 2017, Kulzer operated under the name of Heraeus Kulzer. By changing the name, Kulzer will focus on its strengths that have made it successful: loyal partnerships with users, distributors and universities, and, above all, highest quality materials, innovations and a spectrum of services that is unique in the market.
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Avalon NeoMTA Plus® Named Top Endodontic Reparative Cement for Fourth Straight Year

Easy-mixing, versatile, yet highly affordable bioceramic again honored by THE DENTAL ADVISOR
HOUSTON, TEXAS, February 7, 2018—Avalon Biomed, a division of NuSmile Ltd., announced today that its Avalon NeoMTA Plus has been named “Top Product” for the Endodontic Reparative Cement category by THE DENTAL ADVISOR for the fourth consecutive year.
“We’re thrilled to have THE DENTAL ADVISOR’s expert group of clinical advisors bestow this prestigious honor on Avalon NeoMTA Plus four years in a row,” said Mark Binford, Avalon Biomed Senior Vice President. “We pride ourselves on this breakthrough product’s ability to offer endodontists and general dentists a combination of versatility, ease of use, and remarkable affordability they simply can’t get from any other dental bioceramic material.”
NeoMTA Plus is a stain-proof, tricalcium silicate-based bioceramic cement that can be used universally for a wide variety of endodontic treatments including pulp therapy. Priced at roughly one- fifth the price of the best-known MTA brands, NeoMTA Plus is praised for its superior abilities to mix smoothly, place easily, resist washout, set quickly and avoid staining.
THE DENTAL ADVISOR awards, among the most highly coveted honors in the dental industry, were created to recognize quality products and equipment whose superiority is documented through clinical and evidence-based research.
For more information on NeoMTA Plus or other Avalon Biomed products, call (941) 896-9948 or visit
About Avalon Biomed
Avalon Biomed, a wholly owned division of NuSmile Ltd., develops, markets and sells highly differentiated bioceramics for use in restorative dentistry applications. Avalon’s products have a variety of uses in vital pulp therapy and endodontics, from pulpotomy and cavity liners to root-end filling and sealer materials. Dr. Carolyn Primus, a renowned materials scientist and 2016 Dr. Edward B. Shils Award winner, founded Avalon Biomed Inc. in 2011 to develop unique, best-in-class medical devices for dentistry and orthopedics. Avalon products are focused on bioactive, inorganic hydraulic formulas utilizing the latest in materials technology.
NuSmile Ltd., Headquartered in Houston, Texas, NuSmile is a worldwide leader in restorative dentistry products. NuSmile has a passion for quality and innovation and an unmatched dedication to the dental profession and the patients they serve. NuSmile products are offered in over 40 countries around the world.
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New Lares Attachments Fit All Electric Motors

February 7, 2018: (Chico, California)— Lares Research has introduced its new ProStyle E Electric Motor Classic Attachments, which are compatible with all leading electric handpiece motor brands and models. Lares electric handpieces and their components are designed to deliver exceptional power, precision, and quality while minimizing hand fatigue.
ProStyle E attachments are precision crafted for smooth, reliable performance. They consist of a 1:5 highspeed fiber-optic contra angle for friction-grip burs, a 1:1 lowspeed fiber optic contra angle for latch type burs, and a straight attachment for 3/32 shank burs. The 1:5 and 1:1 contra angles feature anti-burn ceramic ball interface push buttons and twin-beam solid-rod optics for shadow-free visibility and bright illumination. Both contra angles include tri-port spray capability to ensure unobstructed cooling. 
Affordably priced and covered by a 2-year warranty, ProStyle E contra angles and straight attachments can be ordered from Lares Research factory direct online at:, or by calling toll free: 1-888-333-8440, Ext. 1.
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Dentsply Sirona Digital Dentures Announces Further Expansion Internally and Externally:

Company Expands Digital Denture Possibilities with inLab® MC X5 Capabilities Powered by New inLab®SW 18, and D

GSHAPE and imes-icore® Collaboration

DENTSPLY SIRONA Inc. (“Dentsply Sirona”) (NASDAQ: XRAY) Dentsply Sirona is pleased to announce that the upcoming Q1 launch of inLab SW 18 will allow Dentsply Sirona inLab users the ability to mill Digital Dentures right in-house using the inLab MC X5 milling unit.
In addition, following a one-and-a-half-year successful strategic collaboration with AvaDent® Digital Dental Solutions, The Dental Solutions Company® today announced that both DGSHAPE Corporation and imes-icore have joined the Dentsply Sirona Digital Denture team as selected partners.   
York, Pennsylvania, February 5, 2018. Dentsply Sirona, The Dental Solutions Company®, today announced several strategic collaborations set to further enhance its Digital Denture solutions. Foremost, with the upcoming Q1 introduction of inLab®SW 18, inLab users will be able to mill Digital Dentures right in-house, while still having the option to outsource to AvaDent®. In addition, starting in Q1 of 2018, both DGShape Corporation and imes-icore have partnered with the Company to provide even more innovative Digital Denture solutions.
Specifically, labs that use inLab MC X5 milling units and/or DGSHAPE, imes-icore will be able to mill Dentsply Sirona Digital Dentures in-house after they are designed by AvaDent.  
“These collaborations are an exciting endeavor, and completely synergistic with the Dentsply Sirona vision to deliver innovative dental solutions to improve oral health worldwide,” remarked Tom Leonardi, Dentsply Sirona Group Vice President, Global Prosthetics. “Together we will advance digital denture solutions in the dental lab market, bringing Dentsply Sirona’s market leadership in removable prosthetic materials and CAD/CAM solutions. All collaborations contribute substantially to creating real value for the dental laboratory, the dentist and, ultimately, the patient in the field of digital dentures. In this spirit, it is a pleasure to officially welcome DGSHAPE and imes-icore as our new partners in digital dentures. Both companies are a great complement to our product line, and I believe that these agreements greatly underscore our commitment as a leader in removable prosthetics.”

Kohei Tanabe, President of DGSHAPE Corporation, Hamamatsu-shi, commented, “Our driving force is to fuse human creativity with digital technologies in order to provide simplicity. We are proud to have been chosen by Dentsply Sirona as a selected partner for the effortless production of dental prosthetics. With Dentsply Sirona, the leading company in the dental area, we are embarking on an exciting and promising future technology journey. For our existing and prospective customers this new partnership will expand the power of our products, and the breadth of their services.”

Christoph Stark, Chief Executive Officer of imes-icore, mirrored Tanabe’s sentiments, “Our Company specializes in implementing components to create superior systems in dental technology. In this area, partners are essential for the development of upgrades and applications. The fact that Dentsply Sirona specializes in digital denture solutions for dental labs provides us with a great deal of certainty that, together, we are promoting a promising future technology. We are proud to be a part of this digital revolution.”
Whether users choose to mill in-house or scan and outsource the entire process, Dentsply Sirona Digital Dentures continue to offer flexible solutions and provide superior results.  
For more information about Dentsply Sirona Digital Dentures, please visit

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